Anti-Cancer Research at HWS Receives National Funding – Hobart and William Smith Colleges \
The HWS Update

Anti-Cancer Research at HWS Receives National Funding

A chemistry professor at Hobart and William Smith Colleges has received funding from the National Science Foundation for her anti-cancer research. The award will enable an increase in computational chemistry research at the Colleges.

September 27, 2002 GENEVA, N.Y.—Carol Parish, assistant professor of chemistry, has learned that the National Science Foundation will be providing $72,000 to fund her work on anti-cancer drugs at Hobart and William Smith Colleges. The project titled “Cycloaromatization of Arenediynes” explores the electronic molecular effects associated with anti-cancer warhead drugs called enediynes. Enediynes are a class of molecules referred to as prodrugs. Prodrugs are drugs whose molecular behavior can be controlled such that they are activated only in the presence of a cancer cell, thus avoiding the harmful side effects associated with many chemotherapeutic treatments.

Parish’s research will investigate the electronic nature of these drugs using computational chemistry methods. The research will utilize Beowulf supercomputer clusters at Hobart and William Smith as well as the supercomputer, MERCURY, located at Hamilton College. The money will be used to support summer research fellowships for chemistry and biochemistry undergraduates at Hobart and William Smith Colleges. The funding will also allow for students and faculty to attend national conferences to present the results of their calculations as well as to publish the results of their work in peer review journals.

Parish joined the Hobart and William Smith faculty in 1997 after completing a Fujitsu post-doctoral fellowship in chemistry at Columbia University. She holds a Ph.D. in chemistry from Purdue University and completed her undergraduate training in chemistry at Indiana University Purdue University in Indianapolis.