Julia James, a junior at William Smith, has been selected by the Merck Foundation to present her research during the student poster session at the AAAS annual meeting in Denver, Colo., this coming February. James is one of 25 Merck scholars chosen to present at the meeting. Merck will be sponsoring her trip.
James, of Brooklyn, N.Y. worked with Professor Parish and presented a paper titled “Comparing the Conformational Flexibility of HIV-1 Inhibitors” at the 224th American Chemical Society National Meeting in Boston this summer. James used the Low Mode/Monte Carlo conformational search method to investigate the molecular flexibility and behavior of BMS-232632, saquinavir and tipranavir. Her results indicate that tipranavir's behavior is quite different from the other inhibitors studied, particularly with respect to free solvent size and solvent accessible surface area.