Research on a new series of polyaromatic hydrocarbons published in the Journal of Organic Chemistry
(Nov. 8, 2004) GENEVA, N.Y.— Carol Parish, associate professor of chemistry at Hobart and William Smith Colleges, along with her student, Hobart junior Max Macaluso, recently had the results of their research published in the Journal of Organic Chemistry.
Their research is the theoretical study of undiscovered polyaromatic hydrocarbons. This work used quantum mechanics to look for interesting alternatives to the Bergman cyclization, a process important to the function of a new class of anticancer compounds, called enediynes. This work will further the understanding of the complex reactions of these drugs and will be used to design better anticancer therapies.
While investigating new approaches to the cyclization, Macaluso and Parish, in collaboration with Roald Hoffmann (Nobel Laureate ’81) at Cornell University and Larry Scott at Boston College, stumbled upon a new series of stable, isomeric, polyaromatic compounds. These new compounds could be important precursors to the formation of buckminsterfullerene molecules, also called buckyballs.
For a limited time, the article will be accessible on the journal’s Web site at http://pubs.acs.org/journals/joceah/; scroll down to page 8093.
Macaluso, the son of Nicholas and Grace Macaluso of Canandaigua, is a biochemistry major and an environmental studies minor. He is the recipient of a 2003 Merck/American Association for the Advancement of Science Summer Research Fellowship, as well as a 2004 Patchett Summer Research Fellowship. Macaluso has presented his results on the electronic structure of anti-cancer enediyne warhead drugs at the 2003 and 2004 MERCURY conference on computational chemistry, at Cornell University, at the 2004 national American Chemical society meeting in Philadelphia and in numerous regional and local forums. A Hobart Dean’s Scholar, Macaluso has received the CRC First-Year Chemistry Achievement Award and the PolyEd Award for Achievement in Organic Chemistry.
Parish came to Hobart and William Smith in 1997. She earned the B.S. and M.S. at Indiana University-Purdue University, the Ph.D. at Purdue University, and held the Fujitsu Post-Doctoral Fellowship at Columbia University. She is the author of more than 26 invited presentations and 15 peer-reviewed publications. In addition, she is a visiting assistant professor at Cornell University.
The chemistry department at Hobart and William Smith Colleges has an ambitious chemistry curriculum approved by the American Chemical Society and a national reputation for research involving undergraduate scientists. Faculty within the chemistry department encourage all students to become involved in research, and most chemistry and biochemistry majors at the Colleges present their work at regional and national meetings. Many also publish the results of their work in peer-reviewed journals. This experience gives our students the chance to explore their talents and inclinations for research as well as to experience first hand the practice of the discipline that they study.