Chemistry research conducted through student-faculty collaboration is published in the “Journal of Inorganic and Organometallic Polymers”
March 18, 2003 GENEVA, N.Y.—The work of Jennifer Pratt, a William Smith senior, in collaboration with Chemistry Professors Carol Parish and Martel Zeldin, was published in December 2002 in an article titled “Conformational Analysis and Modeling Studies of Synthetic 4-Dialkylaminopyridine-Siloxane Oligomers with Selective Esterase Activity” in the “Journal of Inorganic and Organometallic Polymers.”
This work investigates the molecular behavior of a synthetic enzyme precursor. Enzymes catalyze specific reactions and chemists would like to be able to construct molecular systems that mimic biologically important enzymes. In this work, catalytic and binding domains were incorporated into the molecular system and conformational searching methods were used to determine the overall, dynamical 3-D molecular behavior and shape. This work is the first known publication on the molecular behavior of these important siloxane-based enezyme mimics.
Edited by Zeldin, the “Journal of Inorganic and Organometallic Polymers” is a comprehensive resource for reports on the latest theoretical and experimental research. The quarterly journal encompasses a broad range of synthetic and natural substances, which contain main group, transition, and inner transition elements. The publication includes fully peer-reviewed papers and shorter communications that address the synthesis, characterization, evaluation, and phenomena of inorganic and organometallic polymers.
Pratt, of Rochester, is a chemistry major who intends to earn a Ph.D. in chemistry and work for the forensic science division of a government agency.
Parish came to Hobart and William Smith Colleges in 1997. She earned the B.S. and M.S. at Indiana University-Purdue University, the Ph.D. at Purdue University and received post-doctoral training at Columbia University. She is the author of more than 15 peer reviewed publications and has raised more than $430,000 to support undergraduate research at HWS.
Zeldin holds a Ph.D. from The Pennsylvania State University. He is also the author of more than 90 peer reviewed papers and edited books. Before joining the Colleges in 1998 he was dean of science and technology at the College of Staten Island of the City University of New York.